Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides.

ABSTRACT: A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.

SUBMITTER: Molander GA 

PROVIDER: S-EPMC4470619 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature