Detection of Mycobacterium tuberculosis Complex in New World Monkeys in Peru.

ABSTRACT: The Mycobacterium tuberculosis complex causes tuberculosis in humans and nonhuman primates and is a global public health concern. Standard diagnostics rely upon host immune responses to detect infection in nonhuman primates and lack sensitivity and specificity across the spectrum of mycobacterial infection in these species. We have previously shown that the Oral Swab PCR (OSP) assay, a direct pathogen detection method, can identify the presence of M. tuberculosis complex in laboratory and free-ranging Old World monkeys. Addressing the current limitations in tuberculosis diagnostics in primates, including sample acquisition and pathogen detection, this paper furthers our understanding of the presence of the tuberculosis-causing bacteria among New World monkeys in close contact with humans.

SUBMITTER: Rosenbaum M 

PROVIDER: S-EPMC4470872 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature