Factors predictive of relapse of acute leukemia in children after allogeneic hematopoietic cell transplantation.

ABSTRACT: The presence of minimal residual disease (MRD) before transplantation is the most important prognostic risk factor predictive of post-transplantation relapse in hematologic malignancies. However, MRD alone does not adequately predict relapse in all patients. To improve upon the ability to identify patients likely to relapse, we evaluated risk factors, in addition to MRD, that may be associated with development of post-transplantation relapse. In this single institution, retrospective cohort study of children with acute leukemia or myelodysplastic syndrome who had undergone a first allogeneic transplantation and had pretransplantation MRD evaluation, 40 of 93 patients (43%) experienced relapse. Univariate analysis demonstrated that African American race, high initial white blood cell count,

SUBMITTER: Shah NN 

PROVIDER: S-EPMC4471051 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature