The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.

ABSTRACT: An association between mast cells and tumor angiogenesis is known to exist, but the exact role that mast cells play in this process is still unclear. It is thought that the mediators released by mast cells are important in neovascularization. However, it is not known how individual mediators are involved in this process. The major constituents of mast cell secretory granules are the mast cell specific proteases chymase, tryptase, and carboxypeptidase A3. Several previous studies aimed to understand the way in which specific mast cell granule constituents act to induce tumor angiogenesis. A body of evidence indicates that mast cell proteases are the pivotal players in inducing tumor angiogenesis. In this review, the likely mechanisms by which tryptase and chymase can act directly or indirec

SUBMITTER: de Souza Junior DA 

PROVIDER: S-EPMC4471246 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature