In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence.

ABSTRACT: The ability to recognize facial expressions of emotion in others is a cornerstone of human interaction. Selective impairments in the recognition of facial expressions of fear have frequently been reported in chronic cocaine users, but the nature of these impairments remains poorly understood. We used the multivariate method of partial least squares and structural magnetic resonance imaging to identify gray matter brain networks that underlie facial affect processing in both cocaine-dependent (n = 29) and healthy male volunteers (n = 29). We hypothesized that disruptions in neuroendocrine function in cocaine-dependent individuals would explain their impairments in fear recognition by modulating the relationship with the underlying gray matter networks. We found that cocaine-dependent indivi

SUBMITTER: Ersche KD 

PROVIDER: S-EPMC4471289 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature