Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia.

ABSTRACT: Schizophrenia is increasingly thought of as a brain network or connectome disorder and is associated with neurodevelopmental processes. Previous studies have suggested the important role of anatomical distance in developing a connectome with optimized performance regarding both the cost and efficiency of information processing. Distance-related disturbances during development have not been investigated in schizophrenia. To test the distance-related miswiring profiles of connectomes in schizophrenia, we acquired resting-state images from 20 adulthood-onset (AOS) and 26 early-onset schizophrenia (EOS) patients, as well as age-matched healthy controls. All patients were drug naive and had experienced their first psychotic episode. A novel threshold-free surface-based analytic framework was de

SUBMITTER: Jiang L 

PROVIDER: S-EPMC4471290 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature