CsrR, a Paralog and Direct Target of CsrA, Promotes Legionella pneumophila Resilience in Water.

ABSTRACT:

Unlabelled

Critical to microbial versatility is the capacity to express the cohort of genes that increase fitness in different environments. Legionella pneumophila occupies extensive ecological space that includes diverse protists, pond water, engineered water systems, and mammalian lung macrophages. One mechanism that equips this opportunistic pathogen to adapt to fluctuating conditions is a switch between replicative and transmissive cell types that is controlled by the broadly conserved regulatory protein CsrA. A striking feature of the legionellae surveyed is that each of 14 strains encodes 4 to 7 csrA-like genes, candidate regulators of distinct fitness traits. Here we focus on the one csrA paralog (lpg1593) that, like the canonical csrA, is conserved in all 14 strains surveye

SUBMITTER: Abbott ZD 

PROVIDER: S-EPMC4471563 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature