Predictors of interleukin-33 and thymic stromal lymphopoietin levels in cord blood.

ABSTRACT:

Background

The fetal immune system is a critical window of development. The epithelial cell-derived cytokines, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) have received attention for their role in allergic responses but not been studied during this critical window. The objectives were to assess correlations among IL-33, TSLP, and IgE in umbilical cord blood samples and identify prenatal predictors of these biomarkers.

Methods

This study utilized data and banked cord blood collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analytic sample comprised the 1254 women with a singleton, term birth with a cord blood sample. Spearman correlation coefficients (SCC) and logistic

SUBMITTER: Ashley-Martin J 

PROVIDER: S-EPMC4471622 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature