Detection of trace metallic elements in oral lichenoid contact lesions using SR-XRF, PIXE, and XAFS.

ABSTRACT: Oral lichen planus (OLP) and oral lichenoid contact lesions (OLCL) are chronic inflammatory mucocutaneous reactions with a risk of malignant transformation that alter the epithelium. OLP and OLCL have similar clinical and histopathological features and it is difficult to distinguish one from the other. Metallic restorations are suspected to generate OLCLs. Trace metal analysis of OLCL specimens may facilitate the discrimination of symptoms and identification of causative metallic restorations. The purpose of this study was to assess OLCL tissue samples for the prevalence of metallic elements derived from dental restorations, and to discriminate OLCL from OLP by using synchrotron radiation-excited X-ray fluorescence analysis (SR-XRF), particle-induced X-ray emission (PIXE), and X-ray absorp

SUBMITTER: Sugiyama T 

PROVIDER: S-EPMC4471725 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature