Extensive rewiring of epithelial-stromal co-expression networks in breast cancer.

ABSTRACT:

Background

Epithelial-stromal crosstalk plays a critical role in invasive breast cancer pathogenesis; however, little is known on a systems level about how epithelial-stromal interactions evolve during carcinogenesis.

Results

We develop a framework for building genome-wide epithelial-stromal co-expression networks composed of pairwise co-expression relationships between mRNA levels of genes expressed in the epithelium and stroma across a population of patients. We apply this method to laser capture micro-dissection expression profiling datasets in the setting of breast carcinogenesis. Our analysis shows that epithelial-stromal co-expression networks undergo extensive rewiring during carcinogenesis, with the emergence of distinct network hubs in normal breast, and estrogen re

SUBMITTER: Oh EY 

PROVIDER: S-EPMC4471934 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature