Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide.

ABSTRACT: A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.

SUBMITTER: Wu B 

PROVIDER: S-EPMC4472006 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature