Spatial Control of Biochemical Modification Cascades and Pathways.

ABSTRACT: Information transmission in cells occurs through complex networks of proteins and genes and is relayed through cascades of biochemical modifications, which are typically studied through ordinary differential equations. However, it is becoming increasingly clear that spatial factors can strongly influence chemical information transmission in cells. In this article, we systematically disentangle the effects of space in signaling cascades. This is done by examining the effects of localization/compartmentalization and diffusion of enzymes and substrates in multiple variants of chemical modification cascades. This includes situations where the modified form of species at one stage 1) acts as an enzyme for the next stage; 2) acts as a substrate for the next stage; and 3) is involved in phosphotr

SUBMITTER: Alam-Nazki A 

PROVIDER: S-EPMC4472220 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature