Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.

ABSTRACT:

Study question

Is there a relationship between the genetic risk for polycystic ovary syndrome (PCOS) and genetic variants that influence timing of menopause?

Summary answer

The genetic risk score, which sums the contribution of variants at all menopause loci, was associated with PCOS.

What is already known

Ovarian parameters and anti-Mullerian hormone levels suggest that women with PCOS should have a later age at menopause.

Study design, size, duration

The study was a case-control examination of genetic variants associated with age at menopause in a discovery cohort of women with PCOS (n = 485) and controls (n = 407) from Boston recruited from 2003 to 2012. Replication was performed in women from Greece (cases, n = 884 and controls, n = 311).

Participants/ma

SUBMITTER: Saxena R 

PROVIDER: S-EPMC4472323 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature