Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology.

ABSTRACT: Perhaps the most mature area of multi-scale systems biology is the modelling of the heart. Current models are grounded in over fifty years of research in the development of biophysically detailed models of the electrophysiology (EP) of cardiac cells, but one aspect which is inadequately addressed is the incorporation of uncertainty and physiological variability. Uncertainty quantification (UQ) is the identification and characterisation of the uncertainty in model parameters derived from experimental data, and the computation of the resultant uncertainty in model outputs. It is a necessary tool for establishing the credibility of computational models, and will likely be expected of EP models for future safety-critical clinical applications. The focus of this paper is formal UQ of one major

SUBMITTER: Pathmanathan P 

PROVIDER: S-EPMC4472478 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature