Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells.

ABSTRACT: Understanding the role of mechanical forces on cell behavior is critical for tissue engineering, regenerative medicine, and disease initiation studies. Current hemodynamic bioreactors are largely limited to 2D substrates or the application of general flow conditions at a tissue level, which eliminates the investigation of some essential physiological and pathological responses. One example is the mesenchymal transformation of endothelial cells in response to shear stress. Endothelial to mesenchymal transformation (EndMT) is a valve morphogenic mechanism associated with aortic valve disease initiation. The aortic valve experiences oscillatory shear on the disease-susceptible fibrosa, and the role of hemodynamics on adult EndMT is unknown. The goal of this work was to develop and characteriz

SUBMITTER: Mahler GJ 

PROVIDER: S-EPMC4472486 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature