Cardiac response to low-energy field pacing challenges the standard theory of defibrillation.

ABSTRACT:

Background

The electric response of myocardial tissue to periodic field stimuli has attracted significant attention as the basis for low-energy antifibrillation pacing, potentially more effective than traditional single high-energy shocks. In conventional models, an electric field produces a highly nonuniform response of the myocardial wall, with discrete excitations, or hot spots (HS), occurring at cathodal tissue surfaces or large coronary vessels. We test this prediction using novel 3-dimensional tomographic optical imaging.

Methods and results

Experiments were performed in isolated coronary perfused pig ventricular wall preparations stained with near-infrared voltage-sensitive fluorescent dye DI-4-ANBDQBS. The 3-dimensional coordinates of HS were determined using alterna

SUBMITTER: Caldwell BJ 

PROVIDER: S-EPMC4472493 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature