Thalamic-hippocampal-prefrontal disruption in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Cortical, thalamic and hippocampal gray matter atrophy in relapsing-remitting MS (RRMS) is associated cognitive deficits. However, the role of interconnecting white matter pathways including the fornix, cingulum, and uncinate fasciculus (UF) is less well studied.

Objective

To assess MS damage to a hippocampal-thalamic-prefrontal network and the relative contributions of its components to specific cognitive domains.

Methods

We calculated diffusion tensor fractional anisotropy (FA) in the fornix, cingulum and UF as well as thalamic and hippocampal volumes in 27 RRMS patients and 20 healthy controls. A neuropsychological battery was administered and 4 core tests known to be sensitive to MS changes were used to assess cognitive impairment. To determine the rela

SUBMITTER: Kern KC 

PROVIDER: S-EPMC4473119 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature