Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task.

ABSTRACT:

Background

Our previous work characterized altered cerebral activations during cognitive control in individuals with alcohol dependence (AD). A hallmark of cognitive control is the ability to anticipate changes and adjust behavior accordingly. Here, we employed a Bayesian model to describe trial-by-trial anticipation of the stop signal and modeled fMRI signals of conflict anticipation in a stop signal task. Our goal is to characterize the neural correlates of conflict anticipation and its relationship to response inhibition and alcohol consumption in AD.

Methods

Twenty-four AD and 70 age and gender matched healthy control individuals (HC) participated in the study. fMRI data were pre-processed and modeled with SPM8. We modeled fMRI signals at trial onset with individual even

SUBMITTER: Hu S 

PROVIDER: S-EPMC4473266 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature