Heterogeneity of chemokine cell-surface receptor expression in triple-negative breast cancer.

ABSTRACT:

Introduction

Tumor heterogeneity is a well-established concept in cancer research. In this paper, we examine an additional type of tumor cell heterogeneity - tumor cell-surface receptor heterogeneity.

Methods

We use flow cytometry to measure the frequency and numbers of cell-surface receptors on triple negative breast cancer cell lines.

Results

We find two distinct populations of human triple-negative breast cancer cells MDA-MB-231 when they are grown in culture, one with low surface levels of various chemokine receptors and a second with much higher levels. The population with high surface levels of these receptors is increased in the more metastatic MDA-MB-231-luc-d3h2ln cell line.

Conclusion

We hypothesize that this high cell-surface receptor population is i

SUBMITTER: Norton KA 

PROVIDER: S-EPMC4473311 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature