[(18)F]-fluoro-L-thymidine PET and advanced MRI for preoperative grading of gliomas.

ABSTRACT:

Purpose

Conventional MRI based on contrast enhancement is often not sufficient in differentiating grade II from grade III and grade III from grade IV diffuse gliomas. We assessed advanced MRI, MR spectroscopy and [(18)F]-fluoro-l-thymidine ([(18)F]-FLT) PET as tools to overcome these limitations.

Methods

In this prospective study, thirty-nine patients with diffuse gliomas of grades II, III or IV underwent conventional MRI, perfusion, diffusion, proton MR spectroscopy ((1)H-MRS) and [(18)F]-FLT-PET imaging before surgery. Relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC), Cho/Cr, NAA/Cr, Cho/NAA and FLT-SUV were compared between grades.

Results

Cho/Cr showed significant differences between grade II and grade III gliomas (p = 0.03). To discrimi

SUBMITTER: Collet S 

PROVIDER: S-EPMC4474410 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature