MOST+: A de novo motif finding approach combining genomic sequence and heterogeneous genome-wide signatures.

ABSTRACT:

Background

Motifs are regulatory elements that will activate or inhibit the expression of related genes when proteins (such as transcription factors, TFs) bind to them. Therefore, motif finding is important to understand the mechanisms of gene regulation. De novo discovery of regulatory elements, like transcription factor binding sites (TFBSs), has long been a major challenge to gain insight on mechanisms of gene regulation. Recent advances in experimental profiling of genome-wide signals such as histone modifications and DNase I hypersensitivity sites allow scientists to develop better computational methods to enhance motif discovery. However, existing methods for motif finding suffer from high false positive rates and slow speed, and it's difficult to evaluate the performance of

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4474412 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature