Systems analysis of gene ontology and biological pathways involved in post-myocardial infarction responses.

ABSTRACT:

Background

Pathway analysis has been widely used to gain insight into essential mechanisms of the response to myocardial infarction (MI). Currently, there exist multiple pathway databases that organize molecular datasets and manually curate pathway maps for biological interpretation at varying forms of organization. However, inconsistencies among different databases in pathway descriptions, frequently due to conflicting results in the literature, can generate incorrect interpretations. Furthermore, although pathway analysis software provides detailed images of interactions among molecules, it does not exhibit how pathways interact with one another or with other biological processes under specific conditions.

Methods

We propose a novel method to standardize descriptions of en

SUBMITTER: Nguyen NT 

PROVIDER: S-EPMC4474415 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature