High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children.

ABSTRACT:

Background

Carriage of either single or multiple pneumococcal serotypes (multiple carriage) is a prerequisite for developing invasive pneumococcal disease. However, despite the reported high rates of pneumococcal carriage in Malawi, no data on carriage of multiple serotypes has been reported previously. Our study provides the first description of the prevalence of multiple pneumococcal carriage in Malawi.

Methods

The study was conducted in Blantyre and Karonga districts in Malawi, from 2008 to 2012. We recruited 116 children aged 0-13 years. These children were either HIV-infected (N = 44) or uninfected (N = 72). Nasopharyngeal samples were collected using sterile swabs. Pneumococcal serotypes in the samples were identified by microarray. Strains that could not be typed by m

SUBMITTER: Kamng'ona AW 

PROVIDER: S-EPMC4474563 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature