Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction.

ABSTRACT:

Background

Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.

Methodology/principal findings

We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the on

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4474722 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature