The -93T/G LPL Promoter Polymorphism Is Associated With Lower Third-Trimester Triglycerides in Pregnant African American Women.

ABSTRACT:

Background

Hypertriglyceridemia is a risk factor for cardiovascular disease and several pregnancy complications. Lipoprotein lipase (LPL) genetic variation modulates nonpregnancy plasma triglycerides, but its effects during pregnancy are unknown. The G allele of the LPL -93T/G promoter polymorphism is 16-23 times more prevalent in Blacks than in Whites, contributing to lower triglycerides in nonpregnant African Americans by increasing LPL expression.

Purpose

This study investigated whether the triglyceride-lowering effect of -93G is observed in African Americans during pregnancy.

Methods

Genotyping was performed on 124 African American women with uncomplicated pregnancies for common functional LPL polymorphisms/mutations (-93T/G, D9N, N291S, and S447X). Third-trimeste

SUBMITTER: Schmella MJ 

PROVIDER: S-EPMC4474765 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature