Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation.

ABSTRACT: Understanding the fundamental dynamics of epigenome variation during normal aging is critical for elucidating key epigenetic alterations that affect development, cell differentiation and diseases. Advances in the field of aging and DNA methylation strongly support the aging epigenetic drift model. Although this model aligns with previous studies, the role of other epigenetic marks, such as histone modification, as well as the impact of sampling specific CpGs, must be evaluated. Ultimately, it is crucial to investigate how all CpGs in the human genome change their methylation with aging in their specific genomic and epigenomic contexts. Here, we analyze whole genome bisulfite sequencing DNA methylation maps of brain frontal cortex from individuals of diverse ages. Comparisons with blood dat

SUBMITTER: Sun D 

PROVIDER: S-EPMC4475080 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature