Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC4475453 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Wang Wei W Marholz Laura J LJ Wang Xiang X
Journal of biomolecular screening 20150416 6
Jumonji C domain-containing histone demethylases (JHDMs) are epigenetic proteins capable of demethylating methylated lysine residues on histones proteins and for which high-quality chemical probes and eventual therapeutic leads are highly desirable. To expand the extent of known scaffolds targeting JHDMs, we initiated an unbiased high-throughput screening approach using a fluorescence polarization (FP)-based competitive binding assay we recently reported for JHDM1A (aka KDM2A). In total, 14,400 ...[more]