Systematic enrichment analysis of microRNA expression profiling studies in endometriosis.

ABSTRACT:

Objectives

The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers.

Materials and methods

PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRNAs expression data were extracted, and study quality of each article was assessed. The frequently reported miRNAs with consistent regulation were screened out by a meta-profiling algorithm. The putative targets of consistently expressed miRNAs were predicted by using four target prediction tools (TargetScan, PicTar, miRanda, miRDB), and gene ontology pathway enrichment analysis (KEGG and

SUBMITTER: Wei S 

PROVIDER: S-EPMC4475649 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature