Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos.

ABSTRACT: It is well known that gene regulation is a tightly controlled process in early organismal development. However, the roles of key processes involved in this regulation, such as transcription and translation, are less well understood, and mathematical modeling approaches in this field are still in their infancy. In recent studies, biologists have taken precise measurements of protein and mRNA abundance to determine the relative contributions of key factors involved in regulating protein levels in mammalian cells. We now approach this question from a mathematical modeling perspective. In this study, we use a simple dynamic mathematical model that incorporates terms representing transcription, translation, mRNA and protein decay, and diffusion in an early Drosophila embryo. We perform global s

SUBMITTER: McCarthy GD 

PROVIDER: S-EPMC4476099 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature