Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response.

ABSTRACT: It has been proposed that positive selection may be associated with protein functional change. For example, human and macaque have different outcomes to HIV infection and it has been shown that residues under positive selection in the macaque TRIM5α receptor locate to the region known to influence species-specific response to HIV. In general, however, the relationship between sequence and function has proven difficult to fully elucidate, and it is the role of large-scale studies to help bridge this gap in our understanding by revealing major patterns in the data that correlate genotype with function or phenotype. In this study, we investigate the level of species-specific positive selection in innate immune genes from human and mouse. In total, we analyzed 456 innate immune genes using cod

SUBMITTER: Webb AE 

PROVIDER: S-EPMC4476151 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature