Exploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster.

ABSTRACT: A major challenge of modern Biology is elucidating the functional consequences of natural mutations. Although we have a good understanding of the effects of laboratory-induced mutations on the molecular- and organismal-level phenotypes, the study of natural mutations has lagged behind. In this work, we explore the phenotypic space and the evolutionary history of a previously identified adaptive transposable element insertion. We first combined several tests that capture different signatures of selection to show that there is evidence of positive selection in the regions flanking FBti0019386 insertion. We then explored several phenotypes related to known phenotypic effects of nearby genes, and having plausible connections to fitness variation in nature. We found that flies with FBti0019386

SUBMITTER: Ullastres A 

PROVIDER: S-EPMC4476160 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature