Quantitative modeling of dose-response and drug combination based on pathway network.

ABSTRACT:

Background

Quantitative description of dose-response of a drug for complex systems is essential for treatment of diseases and drug discovery. Given the growth of large-scale biological data obtained by multi-level assays, computational modeling has become an important approach to understand the mechanism of drug action. However, due to complicated interactions between drugs and cellular targets, the prediction of drug efficacy is a challenge, especially for complex systems. And the biological systems can be regarded as networks, where nodes represent molecular entities (DNA, RNA, protein and small compound) and processes, edges represent the relationships between nodes. Thus we combine biological pathway-based network modeling and molecular docking to evaluate drug efficacy.

Res

SUBMITTER: Gu J 

PROVIDER: S-EPMC4476235 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature