Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18,168 people with type 1 diabetes: observational study.

ABSTRACT:

Objective

To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes.

Design

Observational study.

Setting

Swedish National Diabetes Register, Sweden 2005-12.

Participants

18,168 people with type 1 diabetes, 2441 using insulin pump therapy and 15,727 using multiple daily insulin injections.

Main outcome measures

Cox regression analysis was used to estimate hazard ratios for the outcomes, with stratification of propensity scores including clinical characteristics, risk factors for cardiovascular disease, treatments, and previous diseases.

Results

Follow-up was for a mean of 6.8 years until December 2012, with 114,135 person years. Wit

SUBMITTER: Steineck I 

PROVIDER: S-EPMC4476263 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature