Generic immunosuppression in solid organ transplantation: systematic review and meta-analysis.

ABSTRACT:

Objective

To compare the clinical efficacy and bioequivalence of generic immunosuppressive drugs in patients with solid organ transplants.

Design

Systematic review and meta-analysis of all studies comparing generic with innovator immunosuppressive drugs.

Data sources

Medline and Embase from 1980 to September 2014.

Review methods

A literature search was performed for all studies comparing a generic to an innovator immunosuppressive drug in solid organ transplantation. Two reviewers independently extracted data and assessed quality of studies. Meta-analyses of prespecified outcomes were performed when deemed appropriate. Outcomes included patient survival, allograft survival, acute rejection, adverse events and bioequivalence.

Results

1679 citations were s

SUBMITTER: Molnar AO 

PROVIDER: S-EPMC4476317 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature