Mortality in Children with Optic Pathway Glioma Treated with Up-Front BB-SFOP Chemotherapy.

ABSTRACT:

Background

In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients.

Methods

We initiated and analyzed a historical cohort study of 180 children with OPG treated in France with BB-SFOP chemotherapy between 1990 and 2004. The survival distributions were estimated using Kaplan-Meier method. The effect of potential risk factors on the risk of death was described using Cox regression analysis.

Results

The OS was 95% [95% CI: 90.6-97.3] 5 years after diagnosis and significantly decreased over time without ever stabilizing: 91.6% at 10 years [95% CI

SUBMITTER: Rakotonjanahary J 

PROVIDER: S-EPMC4476571 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature