Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.

ABSTRACT: A key feature of signalling in dendritic spines is the synapse-specific transduction of short electrical signals into biochemical responses. Ca2+ is a major upstream effector in this transduction cascade, serving both as a depolarising electrical charge carrier at the membrane and an intracellular second messenger. Upon action potential firing, the majority of spines are subject to global back-propagating action potential (bAP) Ca2+ transients. These transients translate neuronal suprathreshold activation into intracellular biochemical events. Using a combination of electrophysiology, two-photon Ca2+ imaging, and modelling, we demonstrate that bAPs are electrochemically coupled to Ca2+ release from intracellular stores via ryanodine receptors (RyRs). We describe a new function mediated by

SUBMITTER: Johenning FW 

PROVIDER: S-EPMC4476683 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature