Fetal exposures and perinatal influences on the stool microbiota of premature infants.

ABSTRACT:

Objective

To test the hypothesis that maternal complications significantly affect gut colonization patterns in very low birth weight infants.

Methods

Forty-nine serial stool samples were obtained weekly from nine extremely premature infants enrolled in a prospective longitudinal study. Sequencing of the bacterial 16S rRNA gene from stool samples was performed to approximate the intestinal microbiome. Linear mixed effects models were used to evaluate relationships between perinatal complications and intestinal microbiome development.

Results

Subjects with prenatal exposure to a non-sterile intrauterine environment, i.e. prolonged preterm premature rupture of membranes (PPPROM) and chorioamnionitis exposure, were found to have a relatively higher abundance of potentiall

SUBMITTER: Chernikova DA 

PROVIDER: S-EPMC4476945 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature