Increased segregation of brain networks in focal epilepsy: An fMRI graph theory finding.

ABSTRACT: Focal epilepsy is conceived of as activating local areas of the brain as well as engaging regional brain networks. Graph theory represents a powerful quantitative framework for investigation of brain networks. Here we investigate whether functional network changes are present in extratemporal focal epilepsy. Task-free functional magnetic resonance imaging data from 15 subjects with extratemporal epilepsy and 26 age and gender matched healthy controls were used for analysis. Local network properties were calculated using local efficiency, clustering coefficient and modularity metrics. Global network properties were assessed with global efficiency and betweenness centrality metrics. Cost-efficiency of the networks at both local and global levels was evaluated by estimating the physical dista

SUBMITTER: Pedersen M 

PROVIDER: S-EPMC4477107 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature