Altered Synchronizations among Neural Networks in Geriatric Depression.

ABSTRACT: Although major depression has been considered as a manifestation of discoordinated activity between affective and cognitive neural networks, only a few studies have examined the relationships among neural networks directly. Because of the known disconnection theory, geriatric depression could be a useful model in studying the interactions among different networks. In the present study, using independent component analysis to identify intrinsically connected neural networks, we investigated the alterations in synchronizations among neural networks in geriatric depression to better understand the underlying neural mechanisms. Resting-state fMRI data was collected from thirty-two patients with geriatric depression and thirty-two age-matched never-depressed controls. We compared the resting-st

SUBMITTER: Wang L 

PROVIDER: S-EPMC4477114 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature