Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.

ABSTRACT:

Background

Abnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.

Methods

Fifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.

Results

Relative to healthy subject, patients exhibited significantly lower VMHC in putamen and cor

SUBMITTER: Luo C 

PROVIDER: S-EPMC4477209 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature