An integrated approach to reveal miRNAs' impacts on the functional consequence of copy number alterations in cancer.

ABSTRACT: Copy number alteration (CNA) is known to induce gene expression changes mainly through dosage effect, and therefore affect the initiation and progression of tumor. However, tumor samples exhibit heterogeneity in gene dosage sensitivity due to the complicated mechanisms of transcriptional regulation. Currently, no high-throughput method has been available for identifying the regulatory factors affecting the functional consequences of CNA, and determining their effects on cancer. In view of the important regulatory role of miRNA, we investigated the influence of miRNAs on the dosage sensitivities of genes within the CNA regions. By integrating copy number, mRNA expression, miRNA expression profiles of three kinds of cancer, we observed a tendency for high dosage-sensitivity genes to be more

SUBMITTER: Li K 

PROVIDER: S-EPMC4477324 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature