Predictive Low-Glucose Insulin Suspension Reduces Duration of Nocturnal Hypoglycemia in Children Without Increasing Ketosis.

ABSTRACT:

Objective

Nocturnal hypoglycemia can cause seizures and is a major impediment to tight glycemic control, especially in young children with type 1 diabetes. We conducted an in-home randomized trial to assess the efficacy and safety of a continuous glucose monitor-based overnight predictive low-glucose suspend (PLGS) system.

Research design and methods

In two age-groups of children with type 1 diabetes (11-14 and 4-10 years of age), a 42-night trial for each child was conducted wherein each night was assigned randomly to either having the PLGS system active (intervention night) or inactive (control night). The primary outcome was percent time <70 mg/dL overnight.

Results

Median time at <70 mg/dL was reduced by 54% from 10.1% on control nights to 4.6% on intervention nig

SUBMITTER: Buckingham BA 

PROVIDER: S-EPMC4477332 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature