Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds.

ABSTRACT:

Background

The domestic dog is a rich resource for mapping the genetic components of phenotypic variation due to its unique population history involving strong artificial selection. Genome-wide association studies have revealed a number of chromosomal regions where genetic variation associates with morphological characters that typify dog breeds. A region on chromosome 10 is among those with the highest levels of genetic differentiation between dog breeds and is associated with body mass and ear morphology, a common motif of animal domestication. We characterised variation in this region to uncover haplotype structure and identify candidate functional variants.

Results

We first identified SNPs that strongly associate with body mass and ear type by comparing sequence variatio

SUBMITTER: Webster MT 

PROVIDER: S-EPMC4477608 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature