QUANTIFYING THE MOTION OF MAGNETIC PARTICLES IN EXCISED TISSUE: EFFECT OF PARTICLE PROPERTIES AND APPLIED MAGNETIC FIELD.

ABSTRACT: This article presents a method to investigate how magnetic particle characteristics affect their motion inside tissues under the influence of an applied magnetic field. Particles are placed on top of freshly excised tissue samples, a calibrated magnetic field is applied by a magnet underneath each tissue sample, and we image and quantify particle penetration depth by quantitative metrics to assess how particle sizes, their surface coatings, and tissue resistance affect particle motion. Using this method, we tested available fluorescent particles from Chemicell of four sizes (100 nm, 300 nm, 500 nm, and 1 µm diameter) with four different coatings (starch, chitosan, lipid, PEG/P) and quantified their motion through freshly excised rat liver, kidney, and brain tissues. In broad terms, we foun

SUBMITTER: Kulkarni S 

PROVIDER: S-EPMC4477713 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature