Self-Reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources.

ABSTRACT: A series of hydrolytically degradable fluorescent poly(ferulic acid-co-tyrosine)-g-mPEG graft copolymers were synthesized and shown to undergo self-assembly in aqueous media to yield fluorescent micelles. The polymers and their micellar assemblies exhibited greater fluorescence emission intensity than did their small molecular building blocks, which provides a self-reporting character that has potential for monitoring the polymer integrity and also for performing in theranostics applications. The amphiphilic graft-copolymers were synthesized by Cu-assisted azide-alkyne "click" addition of azido-functionalized mPEG polymers onto fluorescent degradable hydrophobic copolymers displaying randomly distributed alkyne side-chain groups along their biorenewably d

SUBMITTER: Noel A 

PROVIDER: S-EPMC4477896 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature