Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins.

ABSTRACT: Insulin and its receptor are critical for the regulation of metabolic functions, but the mechanisms underlying insulin receptor (IR) trafficking to the plasma membrane are not well understood. Here, we show that Bardet Biedl Syndrome (BBS) proteins are necessary for IR localization to the cell surface. We demonstrate that the IR interacts physically with BBS proteins, and reducing the expression of BBS proteins perturbs IR expression in the cell surface. We show the consequence of disrupting BBS proteins for whole body insulin action and glucose metabolism using mice lacking different BBS genes. These findings demonstrate the importance of BBS proteins in underlying IR cell surface expression. Our data identify defects in trafficking and localization of the IR as a novel mechanism accounti

SUBMITTER: Starks RD 

PROVIDER: S-EPMC4478011 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature