CSF proteins and resting-state functional connectivity in Parkinson disease.

ABSTRACT:

Objective

The purpose of this study was to investigate the relationship between disruption of MRI-measured resting-state functional connectivity (rs-fcMRI) brain networks and CSF levels of potentially pathogenic proteins that reflect brain pathology in Parkinson disease (PD).

Methods

PD participants without dementia (n = 43) and age-matched controls (n = 22) had lumbar punctures to measure CSF protein levels, Pittsburgh compound B (PiB)-PET imaging, and rs-fcMRI while off medication. Imaging analyses focused on 5 major resting-state networks as well as the striatum.

Results

Participants with PD had significantly reduced sensorimotor functional connectivity, which correlated with reduced CSF levels of α-synuclein. The PD group also had significantly stronger default mo

SUBMITTER: Campbell MC 

PROVIDER: S-EPMC4478033 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature