Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting.

ABSTRACT:

Purpose

Little is known about the impact of alcohol consumption on warfarin safety, or whether demographic, clinical, or genetic factors modify risk of adverse events. We conducted a case-control study to assess the association between screening positive for moderate/severe alcohol misuse and the risk of major bleeding in a community sample of patients using warfarin.

Methods

The study sample consisted of 570 adult patients continuously enrolled in Group Heath for at least 2 years and receiving warfarin. The main outcome was major bleeding validated through medical record review. Cases experienced major bleeding, and controls did not experience major bleeding. Exposures were Alcohol Use Disorders Identification Test Consumption Questionnaire (AUDIT-C) scores and report of he

SUBMITTER: Roth JA 

PROVIDER: S-EPMC4478047 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature