Change in novel filtration markers and risk of ESRD.

ABSTRACT:

Background

Chronic kidney disease progression is a risk factor for end-stage renal disease (ESRD). A 57% decline in creatinine-based estimated glomerular filtration rate (eGFRcr) is an established surrogate outcome for ESRD in clinical trials, and a 30% decrease recently has been proposed as a surrogate end point. However, it is unclear whether change in novel filtration marker levels provides additional information for ESRD risk to change in eGFRcr.

Study design

Cohort study.

Setting & participants

Atherosclerosis Risk in Communities (ARIC) Study participants from 4 US communities.

Predictors

Percent change in levels of filtration markers (eGFRcr, cystatin C-based eGFR [eGFRcys], the inverse of β2-microglobulin concentration [1/B2M]) over a 6-year period.

O

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC4478244 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature