Endothelial Repair in Childhood Arterial Ischaemic Stroke with Cerebral Arteriopathy.

ABSTRACT:

Background

We have previously shown that recurrent arterial ischaemic stroke (AIS) in children with cerebral arteriopathy is associated with increased circulating endothelial cells and endothelial microparticles, consistent with ongoing endothelial injury. To date, however, little is known about endothelial repair responses in childhood AIS. We examined the relationship between the number and function of circulating endothelial progenitor cells (EPC), the levels of brain-derived neurotrophic factor (BDNF) and AIS recurrence.

Methods

Flow cytometry was used to identify peripheral blood mononuclear cells positive for CD34/kinase insert domain-containing receptor (KDR). In a subgroup of patients (5 in each group selected at random), monocytic EPC function was assessed by colony

SUBMITTER: Eleftheriou D 

PROVIDER: S-EPMC4478301 | biostudies-literature | 2015 May-Aug

REPOSITORIES: biostudies-literature